FIELD: pharmacology.
SUBSTANCE: invention concerns biotechnology, specifically to oligomer compound of length 10-30 nucleic bases, and can be used in medicine. The oligomer compound represents a target-binding domain complementary to a segment of 10-18 sequential nucleotides of the region including base position 1459 (5') to 1476 (3') human mRNA Bcl-2 (HUMBcl2A (approach number M13994) in database GenBank), except maximum one inaccurate coupling with specified site of human mRNA Bcl-2 where said target-binding domain is described by formula: 5' - [(DNA/RNA)0-1-(LNA/LNA*)2-7-(DNA/RNA/LNA*)4-14-(LNA/LNA*)2-7-(DNA/RNA)0-1]-3'.
EFFECT: oligomer compound effectively reducing expression of human gene Bcl-2.
25 cl, 20 dwg, 3 tbl, 16 ex
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Authors
Dates
2009-12-27—Published
2004-12-23—Filed