FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to molecular biology and medicine. Presented is using an oligonucleotide having a length of 10-30 nucleotides, which is specifically targeted on a natural antisense transcript of sirtuin 1 (SIRT1), for preventing or treating a sirtuin 1 (SIRT1)-related disease or disorder, wherein the above oligonucleotide increases sirtiun 1 (SIRT1) expression, and wherein the natural antisense transcript has a nucleotide sequence with any of SEQ ID NO:2-5.
EFFECT: presented is using the oligonucleotide for preventing or treating the sirtuin 1 (SIRT1)-related disease or disorder.
19 cl, 20 dwg, 4 ex
