APPLICATION OF SPHINGOSINE-1-PHOSPHATE (SIP) RECEPTOR AGONISTS FOR TREATMENT OF DEGENERATIVE BRAIN DISEASES Russian patent published in 2010 - IPC A61K31/137 A61P25/28 

Abstract RU 2379030 C2

FIELD: medicine.

SUBSTANCE: claimed are pharmaceutical composition, which contains therapeutically efficient amount of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol in free form or in form of pharmaceutically acceptable salt for treatment of progressing dementia or degenerative brain diseases and corresponding method of treatment. Demonstrated is inhibition by compound of monocyte chemotaxis, caused by β-amyloid protein in addition to agonistic activity to SIP receptor.

EFFECT: improvement of memory condition in patients with Alzheimer's disease.

7 cl, 2 tbl

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RU 2 379 030 C2

Authors

Fol'Ker Brinkmann

Nikole Kanajder

Kristian J. Vidermann

Dates

2010-01-20Published

2004-12-17Filed