AMIDE DERIVATIVES CARRYING CYCLOPROPYLAMINOCARBONYL SUBSTITUTE, SUITABLE AS CYTOKINE INHIBITORS Russian patent published in 2010 - IPC C07C237/38 C07D213/30 C07D277/24 C07D285/12 C07D213/68 C07D239/26 C07D401/12 C07D417/12 C07D471/04 C07D277/32 C07D307/68 C07D261/08 A61K31/167 A61K31/426 A61K31/433 A61K31/4427 A61K31/506 A61P11/06 A61P19/02 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula , where Q_a is phenyl or heteroaryl, and Q_a can possibly carry 1 or 2 substitutes selected from hydroxy, halogen, amino, (1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkylamino and di-[(1-6C)alkyl]amino; R₁ and R₂ are each independently selected from hydrogen and (1-6C)alkyl; Qb is phenyl or heteroaryl, and Q_b can possibly carry 1 or 2 substitutes selected from hydroxy, halogen, (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)alkoxy, (1-6C)alkoxycarbonyl, amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, amino-(1-6C)alkyl, (1-6C)alkylamino-(1-6C)alkyl, (1-6C)alkylthio, (1-6C)alkylsulfinyl and (1-6C)alkylsulfonyl; where any of the substitutes Q_a and Q_b defined above, containing a CH₂ group which is bonded to 2 carbon atoms, or a CH₃ group bonded to a carbon atom, can possibly carry on each of the said CH₂ or CH₃ group one or more substitutes selected from hydroxy, amino, (1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkylamino and di-[(1-6C)alkyl]amino; where heteroaryl is an aromatic 5- or 6-member monocyclic ring which can contain up to three heteroatoms selected from oxygen, nitrogen and sulphur, and can be condensed with a benzene ring or a five-member nitrogen-containing ring containing 2 nitrogen atoms; as well as pharmaceutically acceptable salts thereof. The invention also relates to a method of producing formula I compounds, a pharmaceutical composition and use of these compounds for treating conditions mediated by effect of TNF cytokines.

EFFECT: more effective treatment.

13 cl, 3 tbl, 46 ex