ESTERS OF HYALURONIC ACID WITH RHEIN, METHOD OF PREPARING SAID ESTERS AND COMPOSITION CONTAINING SAID ESTERS Russian patent published in 2010 - IPC C08B37/08 A61K31/728 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds based on hyaluronic acid, where alcohol groups of the hyaluronic acid are esterified by rhein in free form or in form of a pharmaceutically active compound derivative in vivo and where the acid group of rhein is capable of forming an ether bond with the hydroxyl group of the hyaluronic acid or its pharmaceutically acceptable salt, to a method of preparing the said ester, which involves reacting acid chloride of rhein in free form or in form of a pharmaceutically active compound derivative in vivo with hyaluronic acid and to a pharmaceutical composition containing said ester, having anti-inflammatory properties and anabolic-reparative activity for local-regional application - for treating inflammatory diseases (inflammatory diseases of joints) or neogenesis (cartilage or skin being the tissue).

EFFECT: more efficient application.

35 cl, 7 dwg, 7 ex