METHOD OF OBTAINING FUNCTIONALISED DERIVATIVES OF HYALURONIC ACID AND FORMATION OF THEIR HYDROGELS Russian patent published in 2014 - IPC C08B37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of polysaccharides. A method of obtaining functionalised derivatives of hyaluronic acid includes activation of at least one hydroxyl group of hyaluronic acid. Hyaluronic acid is taken in the form of a salt soluble in organic solvents. Activation is performed by interaction of the said salt of hyaluronic acid in a polar aprotic solvent with a carbonylating agent. The carbonylating agent is selected from phenyl ethers of carbonic acids and phenyl ethers of haloformic acid. After that, the obtained activated salt of hyaluronic acid by a reaction of a nucleophilic substitution is subjected to interaction with a compound of the general formula NH₂-R. R is selected from NH₂, an aminoalkyl group, alkyl or arylalkyl chains, a polyacryl chain, a polyoxyethylene chain of a drug agent, a polymer or a protein. Also described are functionalised derivatives of hyaluronic acid and based on them hydrogels.

EFFECT: invention makes it possible to obtain hyaluronic acid derivatives for production of cross-linked hydrogels.

24 cl, 4 dwg, 2 tbl, 9 ex