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2 385 937

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(51)

IPC

C12N15/12(2006-01-01)

(21) (22)

Application

2008125416/13, 2008-06-25

(24)

Start date

2008-06-25

(22)

Actual filing date

2008-06-25

(45)

Published

2010-04-10

(72)

Inventor

Vlasik Tat'Jana NikolaevnaShevelev Aleksandr JasenovichParfenova Elena ViktorovnaTkachuk Vsevolod Arsen'EvichRubina Ksenija AndreevnaKalinina Natal'Ja IgorevnaKashirina Natal'Ja Mikhajlovna

(73)

Holder

Vlasik Tat'Jana NikolaevnaRubina Ksenija Andreevna

VEGFopt GENE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR Russian patent published in 2010 - IPC C12N15/12

Abstract RU 2385937 C1

FIELD: medicine.

SUBSTANCE: gene of human vascular endothelial growth factor (VEGF) optimised for expression in mammal cells is presented.

EFFECT: due to introduction of VEGFopt gene into pC4W-VEGFopt plasmid, the invention allows improving the yield of an end product in 1,5 times in comparison with the technology of pC4W-hVEGF165 plasmid containing a natural gene.

3 dwg, 1 ex

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RU 2 385 937 C1

Authors

Vlasik Tat'Jana Nikolaevna

Shevelev Aleksandr Jasenovich

Parfenova Elena Viktorovna

Tkachuk Vsevolod Arsen'Evich

Rubina Ksenija Andreevna

Kalinina Natal'Ja Igorevna

Kashirina Natal'Ja Mikhajlovna

Dates

2010-04-10—Published

2008-06-25—Filed