APPLICATION OF MODIFIED CYCLOSPORINS FOR TREATING HCV INDUCED DISEASES Russian patent published in 2010 - IPC A61K38/13 A61P31/14 

Abstract RU 2389501 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: there is offered application of cyclosporine for preparing a pharmaceutical composition for prevention or treatment of hepatitis C related infections or HCV induced disorders, where cyclosporine (a) is bound with human recombinant cyclophilin with a bound constant (BC) is at least 0.7, where the BC represents a decimal logarithm of the relation of IC50 cyclosporine and IC50 cyclosporine A in simultaneous experiment for estimating by competitive assay ELISA; and (b) exhibits activity in a lymphocyte reaction in a mixed culture 5% and less in comparison with the activity of cyclosporine A, where cyclosporine is [MeIle]cyclosporine or a compound of formula (versions).

EFFECT: prepared compounds inhibit HCV and in treatment do not suppress immune system, can be used in combination with other anti-HCV agents.

12 cl, 2 dwg

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RU 2 389 501 C2

Authors

Khijikata Makoto

Shimotokhno Kunitada

Vatashi Koichi

Dates

2010-05-20Published

2004-09-02Filed