FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, particularly the use of non-immunosuppressive cyclophilin-binding cyclosporine for preventing or treating transplantation-related cirrhosis wherein cyclosporine (I) binds to human recombinant cyclophilin with a binding constant (BR) making less than 0.7 wherein BR represents a common logarithm of IC50 cyclosporine to IC50 cyclosporine A relation in concurrent experiment when evaluating by ELISA procedure; and (II) has activity in lymphocyte assay in the mixed culture making no more than 5% as compared with cyclosporine A activity (cl. 1) of the patent claim. There are also disclosed a pharmaceutical composition and a pharmaceutical combination containing cyclosporine under cl. 1.
EFFECT: group of inventions provides directed action on the elimination of adverse stimuli in liver transplantation.
3 cl
| Title | Year | Author | Number |
|---|---|---|---|
| APPLICATION OF MODIFIED CYCLOSPORINS FOR TREATING HCV INDUCED DISEASES | 2004 |
|
RU2389501C2 |
| NONIMMUNOSUPPRESSIVE CYCLOSPORINE FOR TREATING CONGENITAL ULLRICH MYOPATHY | 2008 |
|
RU2462262C2 |
| CYCLOSPORINE | 1991 |
|
RU2085589C1 |
| MODIFIED CYCLOSPORIN THAT CAN BE USED AS PRODRUG AND ITS USING | 2002 |
|
RU2290196C2 |
| CYCLOSPORIN DERIVATIVES, SUBSTITUTED WITH 3-ETHER AND 3-THIOETHER FOR TREATING AND PREVENTING INFECTIOUS HEPATITIS C | 2005 |
|
RU2399628C2 |
| METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT AND PREVENTION OF HEPATITIS C INFECTION | 2006 |
|
RU2440822C2 |
| DERIVATIVES OF CYCLOSPORIN, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON SAID | 1993 |
|
RU2131883C1 |
| NOVEL CYCLOSPORIN DERIVATIVES FOR TREATMENT AND PREVENTION OF VIRAL INFECTIONS | 2011 |
|
RU2601742C2 |
| APPLICATION OF CYCLOSPORINE AND PEGYLATED INTERFERON COMBINATION FOR HEPATITIS (HCV) TREATMENT | 2005 |
|
RU2394589C2 |
| APPLICATION OF SANGLIFERIN FOR TREATING HEPATITIS C VIRUS | 2006 |
|
RU2427372C2 |
