FIELD: microbiological industry, antibiotics. SUBSTANCE: invention relates to cyclosporines of the formula: 
where: W' - MeBmt or dihydro-MeBmt; X - α-Abu, Val, Nva or MeOThr; R - Sar or (D)-MeAla; Y - MeLeu, g-hydroxy-MeLeu, MeIle, MeVal, MeThr, MeaAla or MeaThr; Z - Val, Leu, MeVal or MeLeu. Condition: when Y means MeLeu or MeAla then Z is MeVal or MeLeu; and if W means MeBmt, R means Sar and Y means g-hydroxy-MeLeu then Z is distinct from Val. EFFECT: new cyclosporine derivative indicated above. 4 cl, 2 tbl
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