METHOD FOR PREDICTION OF BREAST CANCER Russian patent published in 2010 - IPC G01N33/493 G01N33/574 

FIELD: medicine.

SUBSTANCE: highly selective solid-state extraction of an urine sample is followed with qualitative and quantitative analysis for the urine content of the following nucleosides: 1-methyladenosine (Z₁), uridine (Z₂), xanthosine (Z₃), 5-deoxy-5-metylthioadenosine (MTA) (Z₄), cytidine (Z₅), and NN-dimethylguanosine (Z₆). Thus the probability of breast pathology increases if the urine content of uridine, xanthosine, 5-deoxy-5-methylthioadenosine (MTA) and cytidine is increased, while the content of 1-methyladenosine and Nn-dimethylguanosine is decreased. And the probability of breast pathology is estimated by calculating the forecast function F by formula: F=ϕ₁(Z₁)+ϕ₂(Z₂)+ϕ₃(Z₃)+ϕ₄(Z₄)+ϕ₅(Z₅)+ϕ₆(Z₆)+ 71 where: Zn is a concentration of a related nucleoside in the urine sample (mg/ml), ϕn is an identification function of the related nucleoside, F is a predicting function, and by comparing to the age-related chart.

EFFECT: higher prediction effectiveness.

10 cl, 6 ex, 1 tbl, 6 dwg