FIELD: medicine.
SUBSTANCE: invention relates to DPP-4 inhibitor tablet and method of manufacturing compressed tablet by method of direct compressing in form of single dose form. DPP-4 inhibitor represents (S)-1-[(3-hydroxy-1-adamantyl)amino]acetyl-2-cyanopyrrolidin in free form or in form of acid-additive salt. Inert filling agents applied in composition improve friability and compaction characteristics of said medication and tabletted mixture. Optimal friability ensures even stamp filling and mass regulation. Applied binding agent ensures sufficient coherent ability, which allows to compress DPP-4 inhibitor by method of direct compressing.
EFFECT: obtained tablets possess acceptable profile of dissolution in vitro, acceptable degrees of solidity and resistance to breaking.
26 cl, 6 ex
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