FIELD: medicine.
SUBSTANCE: pharmaceutical composition of fast release includes granules obtained by granulation from melt. Granules contain DPP-IV inhibitor and meltable hydrophobic component with ratio from 1:1 to 1:10 (per dry weight). At least 90% of granule surface are covered with meltable hydrophobic component. Granules release approximately 50% of DPP-IV inhibitor during 30 minutes after peroral introduction of medication. DPP-IV inhibitor is N-(substituted glicyl)-2-cyanopyrrolodin or its pharmaceutically acceptable salt. Preferably DPP-IV is (S)-1-[(3-hydroxy-1-adamantyl)amino]acetyl-2-cyanopyrrolidin.
EFFECT: composition for fast release according to invention possesses improved stability in presence of moisture in comparison with known compositions for controlled or prolonged release.
20 cl, 9 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DRY GRANULATION PROCESS FOR PRODUCING TABLET COMPOSITIONS OF METFORMIN AND COMPOSITIONS THEREOF | 2013 |
|
RU2647421C2 |
| NOVEL COMPOSITION | 2006 |
|
RU2483716C2 |
| NEW COMPOSITION | 2006 |
|
RU2821230C2 |
| SOLID DOSAGE FORM FOR ORAL ADMINISTRATION CONTAINING COMBINATION OF VILDAGLIPTIN AND GLIQUIDONE | 2014 |
|
RU2585378C1 |
| METHOD OF OBTAINING COMPOSITIONS BY EXTRUSION OF RESISTANT TO PRESSING PHARMACEUTICAL SUBSTANCES | 2006 |
|
RU2405539C2 |
| PHARMACEUTICAL COMPOSITIONS, CONTAINING IMATINIB AND RELEASE MODERATOR | 2006 |
|
RU2404775C2 |
| METHOD FOR MELT GRANULATION | 2009 |
|
RU2491918C2 |
| COMBINED DELIVERY SYSTEM WITH IMMEDIATE/SUSTAINED RELEASE OF MEDICINAL AGENTS WITH SHORT PERIOD OF HALF-LIFE, INCLUDING FOR REMOGLIFLOZIN | 2011 |
|
RU2596787C2 |
| COMPOSITION AND METHOD OF DIRECT COMPRESSING | 2005 |
|
RU2391097C2 |
| PHARMACEUTICAL COMBINATION, COMPOSITION, AND COMBINED FORMULATION CONTAINING A GLUCOKINASE ACTIVATOR AND A DPP-IV INHIBITOR, AND METHODS FOR PRODUCTION AND APPLICATION THEREOF | 2019 |
|
RU2770775C1 |
