FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, namely to cardiology and can be used for connective tissue density correction following myocardial infarction and pericardiotomy. The method involves triple administration of an inhibitor of a polypeptide sequence containing fragments -Asp-Pro-Lys-Arg-Leu-Tyr-Cys-Asn-Gly-Gly-, -Glu-Arg-Gly-Val-Val-Ser-Ile-Lys-Gly- and -Ala-Asn-Arg-Tyr-Leu-Ala-Met-Lys-Glu-Asp-Gly-Arg-Leu- and having 100 to 240 amino-acid residues in 1.5 and 6 hours and in 3 days after infarction and pericardiotomy started.
EFFECT: use of the invention allows restructuring the forming connective tissue due to changing of the polypeptide sequence concentration in certain distances of a pathological process and thereby reducing fibrosis following myocardial infarction and pericardiotomy.
4 cl, 2 tbl, 5 dwg, 2 ex
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