TETRACYCLIC IMIDAZO-BENZODIAZEPINES AS GAMMA-AMINOBUTYRIC ACID RECEPTORS Russian patent published in 2010 - IPC C07D487/14 A61K31/55 A61P25/00 

FIELD: chemistry.

SUBSTANCE: described are novel imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of formula , where R¹ is hydrogen, halogen, lower alkyl or lower alkoxy, possibly substituted with a halogen, nitro group, C_3-6cycloalkyl, -O(CH₂)_mO(CH₂)_mOH or -C≡C-R'; R² is hydrogen or methyl; R³ is lower alkyl, lower alkenyl, lower alkynyl, possibly substituted with a halogen, -(CH₂)_n-C_3-6cycloalkyl, -(CR'R'')_m-CH₃, phenyl, possibly substituted with a halogen, pyridinyl substituted with a lower alkyl, -(CH₂)_n- NH-C_3-6cycloalkyl, lower alkenyl-C_3-6cycloalkyl, lower alkynyl- (CR'R")_m-OH, lower alkynyl-phenyl, where the phenyl ring is possibly substituted with a halogen, CF₃, lower alkyl or lower alkoxy; R^' is hydrogen or lower alkyl; R" is hydrogen, hydroxy or lower alkyl; n is equal to 0, 1, or 2, m is equal to 1, 2 or 3, o is equal to 1 or 2, or their pharmaceutically acceptable acid addition salts.

EFFECT: obtaining compounds which can be used as a cognitive enhancer or for treating cognitive disorders similar to Alzheimer's disease.

22 cl, 60 ex, 1 tbl