METHOD OF TREATMENT PATIENTS WITH LOCALLY ADVANCED FORMS OF CERVICAL CANCER Russian patent published in 2010 - IPC A61N5/10 A61K31/513 A61K31/713 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology and may be used in treatment of cervical cancer. The method includes chemotherapy with 5-fluorouracil for 5 days every day, followed by simultaneous administering of platinum drugs and radiotherapy according to the scheme of dynamic dose fractionation with extended fractions of 4 Gy to the pelvis during the first 3 days. Then radiation therapy is continued in small fractions of 2.5 Gy once a day up to a total focal dose of 50 Gy, with additionally administered derinat-gel once a day to vaginal tube and simultaneously in the form of microclysters into rectum in scope of 10-15 ml during the first 5 days of treatment. Then for 3-4 hours prior of or 1-2 hours after each session of radiation and after radiation therapy course termination the installations into vaginal tube in the same extent are continued for 2-3 weeks.

EFFECT: method enables to increase resorption of tumor due to increasing the total focal dose up to 50,0 Gy with a decrease in the number and expressivity of radiation reactions due to restoration of oxidative-antioxidant processes and reduce the concentration of free radicals in tissues under influence of derinat gel.

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