DISUBSTITUTED PYRAZOLOBENZODIAZEPINES USED AS CDK2 AND ANGIOGENESIS INHIBITORS, AS WELL AS FOR TREATING MALIGNANT GROWTHS IN MAMMARY GLANDS, LARGE INTESTINES, LUNGS AND PROSTATE GLANDS Russian patent published in 2010 - IPC C07D487/04 A61K31/5517 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention describes novel compounds of general formula: , where R¹ - C₁-C₆alkyl, C₁-C₆alkoxy, halogen, CN, C(O)NH₂ or OCH₂CH₂OCH₃; R²-C₁-C₆alkyl, possibly substituted with halogen, a halogen, C₁-C₆alkoxy, phenyl, N(R⁶)₂, (OCH₂CH₂)_nOCH₃, O(CH₂)_mNR⁷R⁸, where n equals 1 or 2; m equals 2 or 3; R⁶ -R⁷ -C₁C₆alkyl, and R⁸ -OCH₂CH₂OCH₃; or R⁷ and R⁸ together with the nitrogen atom to which they are bonded form a 6-member heterocycle which additionally contains one oxygen atom or one nitrogen atom, which in the latter case is substituted with C₁-C₄alkyl; or R¹ and R² together form a 5-member heterocyclic ring system containing two oxygen atoms as heteroatoms; R³ - hydrogen or C₁-C₆alkyl; R⁴ - hydrogen, halogen or C₁-C₆alkoxy; or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing these compounds.

EFFECT: obtaining novel compounds with kinase inhibiting properties, particularly CDK2, or angiogenesis inhibiting properties and can be used in treating malignant growths, particularly in mammary glands, large intestines, lungs and prostate glands.

60 cl, 7 tbl, 101 ex