FIELD: pharmaceutics.
SUBSTANCE: invention relates to a pharmaceutical composition for increasing patient's glucocerebrosidase the level containing substituted pyrazolopyrimidines and dihydropyrazolopyrimidines of general formula (I) or their pharmaceutically acceptable salts. Group A and substitutes R1-R7 in compounds of formula (I) have the values specified in the patent claim. Invention also relates to a method of Gaucher's disease treatment or Gaucher's disease symptoms prevention and a method of glucocerebrosidase level increasing in patient's leucocytes carrying a GBA gene mutation using composition containing a compound of formula (I) or its pharmaceutically acceptable salt. Besides, invention describes a pharmaceutical composition containing the compound or its pharmaceutically acceptable salt where the compound is selected from a series of specific compounds listed in the patent claim. Invention covers also N-(4-ethynylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide or its pharmaceutically acceptable salt.
EFFECT: pharmaceutical composition for patient's glucocerebrosidase level increasing is proposed.
22 cl, 8 ex
Formula (I)
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | 2013 |
|
RU2660429C2 |
| ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF COMPLEMENT-MEDIATED DISORDERS | 2015 |
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RU2707749C2 |
| PYRAZOLOPYRIMIDINES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1993 |
|
RU2124016C1 |
| PESTICIDES | 1994 |
|
RU2142938C1 |
| METHOD FOR PREPARING CYCLIC DIKETONES | 2003 |
|
RU2316544C2 |
| METHODS AND MEDICAL APPLICATIONS | 2018 |
|
RU2788174C2 |
| COMPOUNDS AND COMPOSITIONS AS CANNABINOID RECEPTOR 1 INHIBITORS | 2005 |
|
RU2431635C2 |
| APPLICATION OF 2-(2-NITRO-4-TRIFLUORMETHYLBENZOYL)-1,3-CYCLOHEXANDIONE IN TREATMENT OF PARKINSON'S DISEASE | 2006 |
|
RU2420272C2 |
| 2-[(DIHYDRO)PYRAZOLYL-3-OXYMETHYLENE]ANILIDES METHOD OF PREPARATION THEREOF, INTERMEDIATE COMPOUNDS, AGENT FOR CONTROLLING AGRICULTURAL PESTS AND HARMFUL FUNGI, AND CONTROL METHODS | 1995 |
|
RU2151142C1 |
| METHODS AND MEDICAL APPLICATIONS | 2018 |
|
RU2788163C2 |
