HUMAN MELANOMA CELL LINE PG WHICH SECRETES RECOMBINANT GRANULOCYTIC-MACROPHAGAL COLONY-STIMULATING FACTOR Russian patent published in 2010 - IPC C12N5/09 C07K14/00 

Abstract RU 2395570 C1

FIELD: chemistry; biochemistry.

SUBSTANCE: invention relates to biotechnology, particularly to obtaining cell lines and can be used for immunotherapy and immunoprophylaxis in patients with malignant growths. The human melanoma cell line PG has stable culture, morphological and immunological characteristics and can secrete a human recombinant granulocytic-macrophagal colony-stimulating factor (GM-CSF). The PG cell line is deposited in the Special collection of cell cultures of cage vertebrates of the Russian collection of cell cultures under number RKKK (P) 702D. All cells of the PG line are characterised by stable secretion of GM-CSF stored after inactivation of cells through exposure to 100 Gy of ionising radiation which reliably prevents proliferation of the inactivated cells.

EFFECT: invention enables introduction of inactivated tumour cells into patients in order to stimulate antitumuor immunity.

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Authors

Berezhnoj Aleksej Evgen'Evich

Larin Sergej Sergeevich

Gnuchev Nikolaj Vasil'Evich

Georgiev Georgij Pavlovich

Zakharova Elena Sergeevna

Lukashina Marina Igorevna

Baryshnikov Anatolij Jur'Evich

Demidov Lev Vadimovich

Mikhajlova Irina Nikolaevna

Burova Ol'Ga Semenovna

Morozova Lidija Fedorovna

Kozlov Aleksej Mikhajlovich

Dates

2010-07-27Published

2008-11-27Filed