FIELD: medicine.
SUBSTANCE: method for increasing immunogenicity of whole-cell anti-cancer vaccines secreting GM-CSF in vitro is enabled by cell incubation in the presence of IFN-γ for 48 hours in the concentration of 10 ng/ml of a culture medium. The application of IFN-γ stimulating MHC expression on the cell surface, increases immunogenicity and specific activity of anti-cancer whole-cell vaccines.
EFFECT: method may be applicable for increasing immunogenicity of anti-cancer whole-cell vaccines.
4 dwg, 1 ex
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