ARYLALKYLCARBAMATE DERIVATIVES, SYNTHESIS AND USE THEREOF IN THERAPY Russian patent published in 2010 - IPC C07C271/48 C07C271/12 C07C269/04 C07C271/16 C07C271/44 C07D277/20 C07D277/40 C07D471/04 A61K31/21 A61K31/426 A61K31/27 A61K31/437 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound which exhibits inhibitory effect on the FAAH enzyme having formula I , where n denotes an integer from 1 to 6; A denotes a group X; where when n equals an integer from 2 to 6, groups A are identical or different; X denotes C_1-2-alkylene; R₁ denotes a hydrogen atom; R₂ denotes a hydrogen atom or a group selected from the following groups: phenyl, phenyloxy; R₃ denotes either 2,2,2-trifluoroethyl or phenyl, if necessary substituted with one or more halogen atoms or C_1-3-alkyl, C_1-3-alkoxy, trifluoromethyl; provided that: the formula 1 compound is not 2,2,2-trifluoroethyl benzylcarbamate, when R₃ denotes 2,2,2-trifluoroethyl and group -[A]_n- denotes a -CH₂- group, when R₃ denotes phenyl, if necessary substituted, and group -[A]_n-denotes a -CH₂-, -CH₂CH₂-,-CH₂CH₂CH₂- group, then R₂ is not a hydrogen atom and is in form of a base, an addition salt with a pharmaceutically acceptable acid, as well as to a method for synthesis of the formula I compound and a pharmaceutical composition having inhibitory effect on FAAH, containing at least one formula I compound.

EFFECT: improved method.

5 cl, 6 ex, 1 tbl