FIELD: chemistry.
SUBSTANCE: invention relates to enantioselective synthesis of intermediate compounds, specifically (-)-trans-(1-methyl-3-(2,4,6-trimethoxyphenyl) pyrrolidin-2-yl)methanol of formula A 
; involving steps on which (-)-trans-1-methyl-5-oxo-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-carboxylic acid of formula E 
is treated with a reducing agent in a solvent. These compounds are used in synthesis of the (+)-trans enantiomer of pyrrolidines substituted with flavones, having formula 1 
, or salts thereof which are cycline-dependant kinase inhibitors and can be used to treat proliferative disorders such as cancer.
EFFECT: method allows efficient large-scale synthesis of the compound by excluding the racemate splitting technique.
15 cl, 12 ex
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