ENANTIOMERICALLY PURE FLAVONE DERIVATIVES FOR TREATMENT OF PROLIFERATIVE DISORDERS AND METHODS OF THEIR OBTAINING Russian patent published in 2011 - IPC C07D207/08 C07D405/04 A61K31/4025 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to enantiomerically pure compound, represented by the following formula (I) or to its pharmaceutically acceptable salt where R₁ represents phenyl, which is substituted with 2 different substituents selected from: halogen, fluoromethyl, difluoromethyl and trifluoromethyl, on condition that if one of substituents on phenyl group represents halogen, the other substituent is not halogen; R₂ and R₃ each is independently selected from: hydroxyl and OR₈; where R₈ represents substituted or unsubstituted C₁-C₁₀-alkyl, C₁-C₄-alkanoyl, substituted or unsubstituted aroyl; R₄ represents C₁-C₄-alkylene hydroxyl; and R₉ represents hydrogen or C₁-C₄-alkyl, to its enantiomerically pure intermediates, to methods of obtaining enantiomerically pure compound (I) and its intermediates, and to pharmaceutical composition, which includes enantiomerically pure compound of formula (I), as well as to application of formula (I) compound for manufacturing medication for cancer treatment.

EFFECT: obtained and described is novel enantiomerically pure compound, which can be usefull in treatment of diseases or disorders, mediated by inhibiting of cyclin-dependent kinase, for instance, cancer.

9 cl, 98 ex, 2 tbl, 3 dwg