2,5-DISUBSTITUTED TETRAHYDROFURANS OR TETRAHYDROTHIOPHENES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS OF TREATMENT Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel 2,5-disubstituted tetrahydrofurans or tetrahydrothiophenes of the formula (I): where Ar means phenyl that is optionally substituted with at least one group taken among halide (including but not limiting with fluorine atom), lower alkoxy- (including methoxy-), lower aryloxy- (including phenoxy-group), cyano-group or R³; m = 1; W means independently -AN(OM)C(O)N-(R⁴)R⁴, -AN-R³-C(O)N(OM)-R⁴, -AN(OM)C(O)-R⁴, AC(O)N(OM)-R⁴, -C(O)N(OM)-R⁴ or C(O)NHA where A means lower alkyl, lower alkenyl or lower alkynyl where one or more carbon atoms can be optionally substituted with O, N or S; M means hydrogen atom, pharmaceutically acceptable cation; X means O, S; Y means O, S, hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, alkaryl; R¹ and R² mean independently hydrogen atom, lower alkyl, halogen atom or COOH; R³ and R⁴ mean independently hydrogen atom, alkyl, alkenyl, alkynyl, C_1-6-alkoxy-C₁-C₁₀-alkyl or C_1-6-alkylthio-C_1-10-alkyl that show an anti-inflammatory activity due to inhibitory effect on activity of 5-lipoxygenase as antagonists of PAF-receptors and show a dual activity, i. e. acting as an antagonist of PAF-receptor and an inhibitor of 5-lipoxygenase. Invention also relates to a pharmaceutical composition based on said compounds and methods of treatment of inflammatory states. EFFECT: improved method of synthesis, valuable medicinal properties. 38 cl, 5 tbl, 5 dwg, 12 ex