METHOD OF PRODUCING ENANTIOMERS OF AMIDOACETONITRILE COMPOUNDS FROM RACEMATES THEREOF Russian patent published in 2011 - IPC C07C255/29 C07C255/44 C07C321/28 C07B57/00 A61K31/277 A61P33/10 

FIELD: chemistry.

SUBSTANCE: method involves 1) dividing a racemate into two pure enantiomers via chromatographic separation on a chiral polysaccharide as a stationary phase with alcohol as the mobile phase and sorption of the eutomer, 2) repeated racemisation of the distomer with a base using a catalyst in a solvent selected from ether or a mixture of solvents containing ether, at temperature between 80°C and 120°C and 3) subjecting the obtained racemate to separation at step 1) in a repeated cycle. The invention also pertains to use of a pure S-enantiomeric form of a formula I compound, particularly (-)-(S)-N-(1-cyano-2-(5-cyano-2-trifluoromethylphenoxy)-1-methylethyl)-4-trifluoromethylsulfanylbenzamide, for control of entozoic parasites of warm-blooded animals, such as helminths.

EFFECT: efficient method of producing a unique enantiomer from a racemate of amidoacetonitrile compound having a formula in which R₁, R₂ and R₃ independently denote cyano, halo-C₁-C₆alkyl or halo-C₁-C₆alkylthio.

15 cl, 1 ex