FIELD: chemical industry. SUBSTANCE: method comprises reacting substrate or salt thereof with racemizing agent selected from strong base, anhydrous salt of metal or carboxylic acid in solvent at from room temperature to 250 C wherein R1 and R2 each is independently selected from group consisting of hydrogen, R and 
: R is selected from C1-5-alkyl, -CH2-aryl, -CH2-heleroaryl wherein aryl is phenyl or naphthyl, and heteroaryl is selected from group consisting of (a) or (c), addition point being any carbon from said heteroaryl. Also described new racemic 2-tert-butyl-carboxamide-4-(3-picolyl) piperazine which is new intermediate compound for preparing compounds which inhibit protease coded by human immune deficiency virus. EFFECT: more efficient racemization method. 21 cl, 21 ex
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Year |
Author |
Number |
| INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF HIV-PROTEASE INHIBITORS AND A METHOD OF THEIR SYNTHESIS |
1994 |
- Dehvid Askin
- Ral'F P.Volante
- Kehn K.Eng
|
RU2125561C1 |
| METHOD OF SYNTHESIS OF INTERMEDIATE COMPOUNDS USED FOR SYNTHESIS OF HIV-PROTEASE INHIBITORS |
1994 |
- Dehvid Askin
- Pol' Rejder
- Kaj Rossen
- Richard Dzh.Varsolona
- Kennet M.Uehlls
|
RU2134263C1 |
| METHOD OF PREPARING EPOXIDE |
1995 |
- Dehvid Askin
- Kehn K.Ehng
- Peter E.Mehligres
- Pol Dzh.Rejder
- Kaj Rossen
- Rol'F P.Volant
- Vina Upadkhaj
|
RU2137769C1 |
| INHIBITORS OF HIV-PROTEASE |
1994 |
- Dzhoel R.Khaff
- Dzhozef P.Vakka
- Brjus D.Dorsi
|
RU2137768C1 |
| COMBINATION OF HIV-PROTEASE INHIBITOR WITH OTHER ANTIVIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND METHOD OF PHARMACEUTICAL COMPOSITION PREPARING |
1994 |
- Dzhozef P.Vakka
- Dzhejms P.Gar
- Brjus D.Dorsi
- M.Katarin Khollouehj
- Rehndall V.Khangejt
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RU2139052C1 |
| DERIVATIVES OF PIPERAZINYLPENTAMIDE AND PHARMACEUTICAL COMPOSITION FOR INHIBITION OF HIV-PROTEASE ACTIVITY |
1992 |
- Dzhozef P.Vakka
- Brjus D.Dorsi
- Dzhejms P.Guar
- Katrin M.Khollovej
- Rehndell V.Khangejt
|
RU2131416C1 |
| METHOD OF PREPARING PIPERAZINYL PENTANEAMIDE AND PIPERAZINYL PENTANEMIDE DERIVATIVE |
1992 |
- Vakka Dzhozef P.
- Dorsi Brjus D.
- Guar Dzhejms P.
- Khollovej Katrin M.
- Khangejt Rehndell V.
|
RU2171254C2 |
| BENZOXAZINONES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF FOR INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, TREATMENT AND PROPHYLAXIS OF AIDS AND ARS, METHOD OF INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, METHOD OF PROPHYLAXIS OF HIV INFECTION, TREATMENT OF HIV AND ARS, COMBINATIONS, METHOD OF SYNTHESIS OF (-)-6-CHLORO- -4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4- -DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE |
1993 |
- Jang Stiven D.
- Britcher Sjuzn F.
- Pejn Linda S.
- Tran Likkhan O.
- Lamma Vill'Jam K. Ml.
|
RU2186775C2 |
| COMBINATION OF INHIBITORS OF HIV-PROTEASE |
1995 |
- Dojch Pol Dzh.
- Ehmini Ehmilio A.
- Vehkka Dzhozef P.
|
RU2194506C2 |
| METHOD OF TREATMENT OF PATIENTS WITH PROSTATE BENIGNITY HYPERPLASIA, PHARMACEUTICAL PREPARATION CONTAINING INHIBITOR OF 5-ALPHA-REDUCTASE |
1992 |
- Glenn Dzh.Gomlej
- Ehlizabet Stoner
|
RU2125879C1 |
