FIELD: chemistry.
SUBSTANCE: invention relates to production of biologically active substances of peptide nature, having cartilage-derived morphogenetic protein CDMP-1 activity on chondrocyte proliferation. Through in silico construction, an oligopeptide of general formula I is obtained: X1-X2-X3-X4 (I), where X1 denotes M; X2 denotes A or G; X3 denotes W; X4 denotes W or is absent.
EFFECT: invention enables to obtain an oligopeptide having cartilage-derived morphogenetic protein CDMP-1 activity on chondrocyte proliferation, thereby widening the range of effective therapeutic agents which accelerate regeneration of cartilage tissue of joints.
5 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OLIGOPEPTIDE HAVING TRANSFORMATION GROWTH FACTOR (TGF-β) AND ONCOSTATIN M (OSM) TOWARDS FIBROBLAST PROLIFERATION | 2008 |
|
RU2385874C2 |
| PEPTIDE SHOWING GROWTH STIMULATING ACTIVITY OF HEPATOCYTE GROWTH FACTOR (HGF) | 2009 |
|
RU2426740C1 |
| OLIGOPEPTIDE HAVING NEUREGULIN-1 ACTIVITY ON CARDIOMYOCYTE PROLIFERATION | 2010 |
|
RU2439078C1 |
| THYROID GLAND FOLLICULAR CELL PROLIFERATION STIMULATING OLIGOPEPTIDE | 2008 |
|
RU2393166C1 |
| PEPTIDE HAVING GROWTH-STIMULATING FACTOR OF HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR | 2008 |
|
RU2385875C2 |
| OLIGOPEPTIDE WITH ACTIVITY OF VASCULAR ENDOTHELIUM GROWTH FACTOR (VEGF) WITH RESPECT TO ANGIOGENESIS STIMULATION | 2008 |
|
RU2375373C1 |
| OLIGOPEPTIDE WITH STEM CELL FACTOR CSF ACTIVITY TOWARDS THYMOCYTE DIFFERENTIATION | 2008 |
|
RU2374262C1 |
| OLIGOPEPTIDE HAVING ACIDIC (aFGF) AND TRANSFORMING (TGF-β) GROWTH FACTOR ACTIVITY TOWARDS STIMULATION OF COLLAGEN BIOSYNTHESIS | 2008 |
|
RU2385873C2 |
| NEUROENDOCRINE FACTORS FOR TREATING DEGENERATIVE DISORDERS | 2008 |
|
RU2496790C2 |
| EXTRACELLULAR MATRIX COMPOSITIONS FOR TREATING CANCER | 2009 |
|
RU2523339C2 |
