ANALYSES AND METHODS USING BIOMARKERS Russian patent published in 2011 - IPC C12Q1/68

Abstract RU 2410438 C2

FIELD: chemistry; biochemistry.

SUBSTANCE: invention relates to biotechnology. The invention discloses methods for analysing expression of one or more biomarkers in a tissue or mammal cell sample. In accordance with the described methods, determination of expression of one or more of such biomarkers is an indicator means that a tissue or cell sample will be sensitive to apoptosis-inducing substances such as agonist antibodies Apo2L/TRAIL and aHTH-DR5. Some biomarkers which can be analysed include fucosyl transferase, in particular fucosyl transferase 3 (FUT3) and/or fucosyl transferase 6 (FUC6), as well as sialyl Lewis A and/or X antigens.

EFFECT: invention widens the range of methods for predicting and treating cancer.

37 cl, 13 dwg, 1 tbl, 1 ex

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RU 2 410 438 C2

Authors

Vagner Klaus V.

Dates

2011-01-27—Published

2005-08-03—Filed