METHODS OF APPLYING OF APO-2L-RECEPTORS AGONISTS AND NK-CELLS ACTIVATORS Russian patent published in 2010 - IPC A61K38/19 A61P35/00 A61P31/00

Abstract RU 2395294 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to experimental medicine and can be applied for amplification of apoptosis or cytolytic activity in cells of mammals. Method and application by invention include bringing mammalian cells in contact with effective quantity of Apo- 2-ligand receptors agonist and resting or unprocessed NK-cells, said agonist is selected from Apo-2-ligand polypeptide, agonistic DR5 antibody and agonistic DR4 antibody.

EFFECT: application of inventions allows amplification of apoptosis and cytolysis induction in tumour cells due to activation by Apo-2-ligand receptors agonist of resting NK-cells.

26 cl, 1 tbl, 18 dwg, 5 ex

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RU 2 395 294 C2

Authors

Godovski Pol Dzh.

Satial Sandzhiv Kh.

Dates

2010-07-27—Published

2005-06-15—Filed