ORGANIC COMPOUNDS Russian patent published in 2011 - IPC C07D401/10 C07D401/12 C07D401/14 C07D405/12 C07D409/10 C07D409/12 C07D413/04 C07D413/12 C07D413/14 C07D417/12 C07D471/04 A61K31/4545 A61P9/00 

Abstract RU 2411239 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula I, in which R1 denotes alkyl or cycloalkyl; R2 denotes phenyl-C1-C7-alkyl, di-(phenyl)- C1-C7-alkyl, naphthyl- C1-C7-alkyl, phenyl, naphthyl, pyridyl-C1-C7-alkyl, indolyl- C1-C7-alkyl, 1H-indazolyl- C1-C7-alkyl, quinolyl C1-C7-alkyl, isoquinolyl- C1-C7-alkyl, 1,2,3,4-tetrahydro-1,4-benzoxazinyl- C1-C7-alkyl, 2H-1,4-benzoxazin-3(4H)-onyl-C1-C7-alkyl, 9-xanthenyl-C1-C7-alkyl, 1-benzothiophenyl-C1-C7-alkyl, pyridyl, indolyl, 1H-indazolyl, quinolyl, isoquinolyl, 1,2,3,4-tetrahydro-1,4-benzoxazonyl, 2H-1,4-benzoxazin-3(4H)-onyl, 9-xanthenyl, 1-benzothiophenyl, 4H-benzo[1,4]thiazin-3-only, 3,4-dihydro-1H-quinolin-2-onyl or 3H-benzoxazol-2-onyl, where each phenyl, naphthyl, pyridyl, indolyl, 1H-indazolyl, quinolyl, isoquinolyl, 1,2,3,4-tetrahydro-1,4-benzoxazonyl, 2H-1,4-benzoxazin-3(4H)-onyl, 1-benzothiophenyl, 4H-benzo[1,4]thiazin-3-only, 3,4-dihydro-1H-quinolin-2-onyl or 3H-benzoxazol-2-onyl are unsubstituted or contain one or up to 3 substitutes independently selected from a group comprising C1-C7-alkyl, hydroxy-C1-C7-alkyl, C1-C7-alkoxy- C1-C7-alkyl, C1-C7-alkoxy- C1-C7-alkoxy-C1-C7-alkoxy- C1-C7-alkyl, C1-C7-alkanoyloxy- C1-C7-alkyl, amino- C1-C7-alkyl, C1-C7-alkoxy- C1-C7-alkylamino- C1-C7-alkyl, C1-C7-alkanoylamino- C1-C7-alkyl, C1-C7-alkylsulphonylamino- C1-C7-alkyl, carboxy- C1-C7-alkyl, C1-C7-alkoxycarbonyl- C1-C7-alkyl, halogen, hydroxy group, C1-C7-alkoxy group, C1-C7-alkoxy- C1-C7-alkoxy group, amino- C1-C7-alkoxy group, N-C1-C7-alkanoylamino-C1-C7-alkoxy group, carbamoyl- C1-C7-alkoxy group, N-C1-C7-alkylcarbamoyl-C1-C7-alkoxy group, C1-C7-alkanoyl, C1-C7-alkoxy-C1-C7-alkanoyl, C1-C7-alkoxy- C1-C7-alkanoyl, carboxyl, carbamoyl and N-C1-C7-alkoxy-C1-C7-alkylcarbamoyl; W denotes a fragment selected from residues of formulae IA, IB and IC, where () indicates the position in which the fragment W is bonded to the carbon atom in position 4 of the piperidine ring in formula I, and where X1, X2, X3, X4 and X5 are independently selected from a group containing carbon and oxygen, where X4 in formula IB and X1 in formula IC can assume one of these values or can be additionally selected from a group comprising S and O, where carbon and nitrogen ring atoms can include a number of hydrogen atoms or substitutes R3 or R4 if contained, taking into account limitations given below, required to bring the number of bonds of the carbon ring atom to 4 and 3 for the nitrogen ring atom; provided that in formula IA at least 2, preferably at least 3 of the atoms X1-X5 denote carbon and in formulae IB and IC at least one of X1-X4 denotes carbon, preferably 2 of the atoms X1-X4 denote carbon; y equals 0 or 1; z equals 0 or 1; R3, which can be bonded with any of the atoms X1, X2, X3 and X4, denotes hydrogen or a C1-C7-alkyloxy-C1-C7-alkyloxy group, phenyloxy-C1-C7-alkyl, phenyl, pyridinyl, phenyl- C1-C7-alkoxy group, phenyloxy group, phenyloxy-C1-C7-alkoxy group, pyridyl-C1-C7-alkoxy group, tetrahydropyranyloxy group, 2H,3H-1,4-benzodioxynyl-C1-C7-alkoxy group, phenylaminocarbonyl or phenylcarbonylamino group, where each phenyl or pyridyl is unsubstituted or contains one or up to 3 substitutes, preferably 1 or 2 substitutes independently selected from a group comprising C1-C7-alkyl, hydroxy group, C1-C7-alkoxy group, phenyl-C1-C7-alkoxy group, where phenyl is unsubstituted or substituted with a C1-C7-alkoxy group and/or halogen; carboxy- C1-C7-alkyloxy group, N-mono- or N,N-di-(C1-C7-alkyl)aminocarbonyl-C1-C7-alkyloxy group, halogen, amino group, N-mono- or N,N-di-(C1-C7-alkyl)amino group, C1-C7-alkanoylamino group, morpholino-C1-C7-alkoxy group, thiomorpholino-C1-C7-alkoxy group, pyridyl-C1-C7-alkoxy group, pyrazolyl, 4- C1-C7-alkylpiperidin-1-yl, tetrazolyl, carboxyl, N-mono- or N,N-di-(C1-C7-alkylamino)carbonyl or cyano group; or denotes 2-oxo-3-phenyltetrahydropyrazolidin-1-yl, oxetidin-3-yl-C1-C7-alkyloxy group, 3-C1-C7-alkyloxetidin-3-yl- C1-C7-alkyloxy group or 2-oxotetrahydrofuran-4-yl- C1-C7-alkyloxy group; provided that if R3 denotes hydrogen, then y and z are equal to 0; R4, if contained, denotes a hydroxy group, halogen or C1-C7-alkoxy group; T denotes carbonyl; and R11 denotes hydrogen, or pharmaceutically acceptable salts thereof. The invention also relates to use of formula I compounds, a pharmaceutical composition, as well as a method of treating diseases.

EFFECT: obtaining novel biologically active compounds having activity towards rennin.

11 cl, 338 ex, 1 tbl

Similar patents RU2411239C2

Title Year Author Number
HETEROCYCLIC COMPOUND, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION 1991
  • Tomas Dzheffri Kolerik Berd[Gb]
RU2070198C1
(AZA)INDOLE-, BENZOTHIOPHENE- AND BENZOFURAN-3-SULPHONAMIDES 2017
  • Mueller Christa E.
  • Pegurier Cecile
  • Deligny Michael Louis Robert
  • El-Tayeb Ali
  • Hockemeyer Joerg
  • Ledecq Marie
  • Mercier Joel
  • Provins Laurent
  • Boshta Nader M.
  • Bhattarai Sanjay
  • Namasivayam Vigneshwaran
  • Funke Mario
  • Schwach Lukas
  • Gollos Sabrina
  • Von Laufenberg Daniel
  • Barre Anais
RU2767904C2
3,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS 2006
  • Ehkhara Takeru
  • Groshe Filipp
  • Irie Osamu
  • Ivaki Juki
  • Kanazava Takanori
  • Kavakami Shimpej
  • Konishi Kazukhide
  • Mogi Muneto
  • Suzuki Masaki
  • Jokokava Fumiaki
RU2415840C2
METHOD OF RESIDUAL LIPOPROTEINS PRODUCING INHIBITION 2004
  • Okamoto Khirosi
  • Furukava Noboru
  • Sasase Tomokhiko
RU2330682C2
ARYL DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND METHODS OF THEIR SYNTHESIS 1991
  • Robert Jan Dovell[Gb]
  • Filip Nejl Ehdvards[Gb]
  • Kejt Oldkhem[Gb]
RU2067976C1
2H- OR 3H-BENZO[E]INDAZOL-1-YL-CARBAMATE DERIVATIVES AND USE THEREOF IN THERAPY 2005
  • Djubua Loran
  • Ehvanno Jannik
  • Maluazel' Kristian
  • Sevren Mirej
RU2379293C2
NOVEL BICYCLIC DERIVATIVES 2020
  • Dyukrej, Per
  • Potra, Fransua
  • Razho, Denis
  • Takhtavi, Shuajb
RU2830113C2
BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, USEFUL IN TREATMENT OF HEPATITIS C 2010
  • Ksav'Er De-Visente-Fidal'Go
  • Tszim Li
  • Rajan Krejg Shenfel'D
  • Fransisko Ksav'Er Talamas
  • Dzhoshua Pol Dzherdzheli Tajdzherli
RU2540332C2
OPENING CYCLES OF LACTONES AND LACTAMS 2010
  • Megan Alin Foli
  • Timoti F. Dzhejmison
  • Ol'Jan Repik
RU2550691C2
METHOD FOR TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY ACTIVITY OF KINASE BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R 2010
  • Nil Gallager
  • Ofeliya In
RU2625835C2

RU 2 411 239 C2

Authors

Brajtenshtajn Verner

Ehkhara Takeru

Ehrkhardt Klaus

Groshe Filipp

Khitomi Juko

Ivaki Juki

Kanazava Takanori

Konishi Kazukhide

Majbaum Jurgen Klaus

Masuja Kejichi

Nikhonjanagi Atsuko

Ostermann Nil'S

Suzuki Masaki

Tojao Atsushi

Jokokava Fumiaki

Dates

2011-02-10Published

2005-12-28Filed