FIELD: medicine.
SUBSTANCE: pH-controlled pulse delivery system according to the invention, contains a nucleus enclosed by an external coating. Said nucleus contains an active substance which is preferentially a pharmaceutically active substance. Said external coating contains a pH-sensitive coating material embedding a swelling ingredient of water swell equal to at least 1.1 in relation to own weight. Said swelling ingredient is present in aforesaid coating in an amount which depending on particle size and structure of the coating forms a coating with a leakless system. The pH-controlled pulse delivery system aims at pH-related place-specific delivery of an active substance preferentially to a large intestine or a duodenum.
EFFECT: invention allows fast release of the active substance owing to the presence of the swelling ingredient in the external coating.
15 cl, 6 dwg, 8 tbl, 5 ex
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