FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to drug form with delayed release for delivery of medication into large intestine. Drug form includes part with core and core coating, where core includes medication and coating. Coating includes mixture of sensitive to influence of large intestine bacteria substance and film-forming polymeric substance, which is not soluble at Ph lower than 5 and soluble at pH higher than 5. As sensitive to influence of large intestine bacteria substance used is starch, containing not more than 75% of amilose. Invention also relates to method of obtaining said drug form, which lies in formation of core and covering core with covering composition, which includes mixture of starch, which contains not more than 75% of amilose, and film-forming polymeric substance.
EFFECT: invention relates to application of claimed drug form for production of medication for treatment of inflammatory disease of intestine and carcinoma, as well as to methods of treating said diseases by introduction of therapeutically efficient amount of claimed drug form.
28 cl, 17 dwg, 1 tbl, 5 ex
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