QUINAZOLINE DERIVATIVES EXHIBITING TYROSINE KINASE INHIBITING ACTIVITY Russian patent published in 2011 - IPC C07D239/34 C07D239/94 C07D401/12 C07D405/06 A61K31/5377 A61P35/00 A61K31/517 A61K31/5375 

Abstract RU 2414457 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new compound presented by general formula (I) where values of Rx, R3, R4, X and A substitutes are described in the patent claim, inhibiting tyrosine kinase of EGF receptor and HER2 tyrosine kinase, as well as to using the compound of formula (I) and pharmaceutical composition containing this compound or its pharmaceutically acceptable salt.

EFFECT: preparation of the tyrosine kinase inhibiting compound.

14 cl, 19 ex, 53 tbl

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RU 2 414 457 C2

Authors

Kume Masakharu

Matsuo Kendzi

Omori Naoki

Takajama Masami

Omori Ajko

Ehndo Takesi

Dates

2011-03-20Published

2006-02-22Filed