CONDENSED HETEROCYCLIC COMPOUND Russian patent published in 2013 - IPC C07D495/04 C07D513/04 C07D519/00 A61K31/519 A61P7/02 A61P9/10 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula 1 , where X and T are N or C, Q is a (3-7)-member aromatic ring which contains 0-3 nitrogen atoms as ring members, and which is optionally benzo-condensed and is substituted with oxo; C₁-C₆-alkyl; halogen- C₁-C₆-alkyl; hydroxy-C₁-C₆-alkyl; C₁-C₆-alkoxy; C₆-C₁₀-aryl; or a (3-7)-member heteroaryl containing 1-3 oxygen atoms, P is C₁-C₆-alkyl, optionally substituted with a halogen, and R is a group selected from: (i) -C₁-C₆-alkyl-R¹, (ii) -NR²R³, (iii) -O-R⁴, (iv) -S-R⁵, (v) -C (=O))-R⁶, (vi) optionally substituted (3-7)-member heteroaryl containing 1-4 heteroatoms selected from a nitrogen atom, an oxygen atom and a sulphur atom, (vi) optionally substituted (3-7)-member heteroatom containing 1-4 heteroatoms selected from a nitrogen atom, an oxygen atom and a sulphur atom, (vii) optionally substituted, saturated or partially unsaturated, separate or condensed (3-10)-member heterocyclic ring containing 1-4 heteroatoms selected from a nitrogen atom, an oxygen atom and a sulphur atom, (viii) azido; where each R¹, R², R³, R⁴, R³, R⁶, is as described in the claim. The invention also relates to a pharmaceutical composition for preventing and treating a vascular disease, which contains a compound of formula 1.

EFFECT: compounds of formula 1 with inhibitory activity with reference to aggregation of thrombocytes.

7 cl, 7 dwg, 2 tbl, 519 ex