EGORLINE DERIVATIVES AND USE THEREOF AS CHEMOKINE RECEPTOR LIGANDS Russian patent published in 2011 - IPC C07D457/06 C07D457/08 A61K31/48 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention describes ergoline derivatives of formula (I), in which each of R₁ and R₂ independently denotes H; optionally R₁₀ and/or R₁₁-substituted phenyl or -phenyl C₁-C₄alkyl; optionally R₁₀ and/or R₁₁-substituted heteroaryl or -heteroaryl C₁-C₄alkyl; optionally R₁₀ and/or R₁₁-substituted N-oxide heteroaryl; optionally R₁₀-substituted C₁-C₈alkyl; optionally R₁₀-substituted C₂-C₈alkenyl; optionally R₁₀-substituted C₂-C₈alkynyl; optionally R₁₀-substituted C₃-C₈cycloalkyl; or optionally R₁₀-substituted C₄-C₈cycloalkenyl; or r₁ and r₂ together with the nitrogen atom to which they are bonded optionally form R₁₀-substituted 3-8-member ring, which, in addition to the nitrogen atom, contains up to 2 heteroatoms independently selected from a group comprising N, O and S; R₃ denotes H; OR₁; CH₂R₁R₂; (CH₂)_1-2NR₁R₂; CH₂-CH₂-OR₁; CH₂-CO-NR₁R₂; or CO-CH₂R₁R₂; R₄ denotes F; CI; Br; I; OR₁, NR₁R₂ or assumes one of the values given for R₁; and R₅ assumes one of the values given for R₁, in free form or in form of a salt for preventing or treating disorders or diseases mediated by interactions between chemokine receptors and their ligands.

EFFECT: high effectiveness of the compounds.

14 cl, 99 ex, 8 tbl