BICYCLIC IMIDAZOL DERIVATIVES AS MEDIUM AGAINST VIRUSES OF FLAVIVIRIDAE FAMILY Russian patent published in 2009 - IPC C07D401/04 C07D401/14 C07D403/04 A61K31/4184 A61P31/12 

FIELD: chemistry.

SUBSTANCE: invention concerns novel bicyclic imidazol derivatives of the general formula I , where: W is CH or N; R is selected out of group including hydrogen, (C₁-C₁₀)alkyl, substituted (C₁-C₁₀)alkyl, (C₃-C₁₀)cycloalkyl and substituted (C₃-C₁₀)cycloalkyl; Z is selected out of group including a) -C(=O)OR⁷, where R⁷ is selected out of group including hydrogen and alkyl; b) -C(=O)NR⁸R⁹, where R⁸ and R⁹ are independently selected out of group including hydrogen, alkyl, aryl, substituted aryl, heterocyclic group, or alternatively R⁸ and R⁹ form heterocyclic group or substituted heterocyclic group, together with nitrogen atom linked to them; c) tetrazolyl; HET is condensed 6,6-bicycle maintained by condensed link of any two 6-member cycles selected out of aryl, cycloalkyl, cycloalkenyl, heterocyclic or heteroaryl cycles optionally substituted by (Y)_q; on the condition that at least one 6-member cycle in bicycle is heterocyclic or heteroaryl; each Y is independently selected out of group including halogen, (C₁-C₁₀)alkyl, substituted (C₁-C₁₀)alkyl, (C₃-C₁₀)cycloalkyl, substituted (C₃-C₁₀)cycloalkyl, heterocyclic group, substituted heterocyclic group, aryl, substituted aryl, heteroaryl, substituted heteroaryl, -CO₂R⁷, -NR¹⁴R¹⁵, -NHNR¹⁴R¹⁵, -C(=O)NR¹⁴R¹⁵, -OR¹⁴, -SR¹⁴; where R⁷ is as defined above, and each of R¹⁴ and R¹⁵ is independently selected out of group including hydrogen, (C₁-C₁₀)alkyl, substituted (C₁-C₁₀)alkyl, aryl, substituted aryl; n is integer equal to 0, 1 or 2; q is integer equal to 1, 2 or 3; where heterocyclic group relates to substituted or non-substituted group with 1 ring or several condensed rings including 1 to 10 carbon atoms and 1 to 2 heteroatoms selected out of group including nitrogen, sulfur and oxygen, inside the ring including optionally 1 to 2 exocarbonyl groups; and pharmaceutically accepted salts or tautomers. Additionally, invention concerns compounds of general formulae II-VIII

and pharmaceutical composition based on compounds of the general formulae I- VIII, XI and XII, and treatment method for mammal virus infection partially mediated by a virus of Flaviviridae virus family, using claimed pharmaceutical composition.

EFFECT: obtaining new compounds, with useful biological effect.

82 cl, 9 tbl, 261 ex