FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to compound of formula I 
in which cycle A represents unsaturated carbocycle with double bonds, which is selected from phenyl or naphtyl; 1 can take value from 1 to 3; m can take value 0, 2 or 3; n can take value 0 or 2; R1 represents a hydrogen atom, (C1-3)alkyl group; R2 represents(C1-6)alkyl group, which is possibly substituted with substituent, selected from C6-cycloalkyl, monocyclic heteroaryl, selected from thiophene, aryl group, selected from phenyl, in form of base or salt of bonding with an acid. Invention also relates to pharmaceutical composition, based on formula I compound, to application of formula I compound for obtaining medication, to method of obtaining formula I compound and to application of formula 
compound for obtaining formula 1 compound.
EFFECT: obtained are novel isoquinoline and benzo[h]isoquinoline derivatives, possessing properties of antagonists of histamine type H3 receptor.
9 cl, 1 tbl, 6 ex
| Title |
Year |
Author |
Number |
| NEW CONDENSED ISOQUINOLINES AS LIGANDS FOR DOPAMINE RECEPTORS |
1996 |
- Nikols Dehvid Eh.
- Mehjlman Richard
- Gosh Debazis
|
RU2177001C2 |
| CYCLOPROPYLAMIDE DERIVATIVES AS N-HISTAMINE RECEPTOR MODULATORS |
2007 |
- Lju Khuatsin
- Blehk Lorens A.
- Bennani Jussef L.
- Kauert Marlon D.
|
RU2449989C2 |
| 1-OXO-3-(1H-INDOL-3-YL)-1,2,3,4-TETRAHYDROISOQUINOLINES, METHODS OF PREPARATION THEREOF, COMBINATORY LIBRARY, AND FOCUSED LIBRARY |
2006 |
- Ivashchenko Aleksandr Vasil'Evich
- Kravchenko Dmitrij Vladimirovich
- Loseva Marina Vasil'Evna
- Okun' Il'Ja Matusovich
- Tkachenko Sergej Evgen'Evich
- Khvat Aleksandr Viktorovich
|
RU2302417C1 |
| HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL AGENT BASED ON THEREOF AND METHOD OF TREATMENT |
2002 |
- Matsui Khirosi
- Kobajasi Khideo
- Azukizava Satoru
- Kasai Masajasu
- Josimi Akikhisa
- Sirakhase Khiroaki
|
RU2299197C2 |
| NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION BASED THEREON, USE THEREOF AND METHOD OF TREATING AND/OR PREVENTING DISEASE |
2009 |
- Uto Josikazu
- Karasava Khirosi
- Takaisi Kijosumi
|
RU2474575C2 |
| AMIDES, PHARMACEUTICAL COMPOSITION, METHODS OF DECREASE OF APOLIPOPROTEIN B SECRETION, COMPOUND |
1996 |
- Dzhorzh Chang
- Piter Kh.Dorff
- Dzhorzh Dzh.Kvollich
|
RU2141478C1 |
| NEW DERIVATIVES OF QUINUCLIDINE AND MEDICINAL COMPOSITIONS CONTAINING THEREOF |
1995 |
- Makoto Takeuti
- Rio Naito
- Masakhiko Khajakava
- Josinori Okamoto
- Jasukhiro Jonetoku
- Ken Ikeda
- Jasuo Isomura
|
RU2143432C1 |
| METHODS FOR PRODUCTION OF RACEMIC AMINOSUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE OR RACEMIC AMINOSUBSTITUTED 5,6,7,8-TETRAHYDROISOQUINOLINE, METHODS FOR SEPARATION AND RACEMIZATION THEREOF, METHODS FOR PRODUCTION OF KETOSUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE OR KETOSUBSTITUTED 5,6,7,8-TETRAHYDROISOQUINOLINE, METHOD FOR PRODUCTION OF ENANTIOMER PF CONDENSED BYCYCLIC RING SUBSTITUTED WITH PRIMARY AMINE, 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES |
2002 |
- Makichern Ehrnest Dzh.
- Bridzher Gari Dzh.
- Skupinska Kristina A.
- Skerldzh Renato T.
|
RU2308451C2 |
| PYRROLO[2,1-A]ISOQUINOLINES |
2009 |
- Van Rejn Rakhel Debora
- Lozen Khubert Jan Jozef
- Timmers Kornelis Marius
- Van Der Ven Lars Anders
- Karstens Villem Frederik Jokhan
|
RU2495037C2 |
| 1 H-IMIDAZOLE DERIVATIVES AS MODULATORS OF CANNABINOID CB2 RECEPTORS |
2006 |
- Lange Jozefus Kh.M.
- Stejvenberg Kherman Kh.
- Van Vliet Bernard J.
|
RU2410377C2 |
