CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2024 - IPC A61K31/506 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: present invention relates to a method for potentiating a therapeutic regimen for treating cancer mediated by DNA-dependent protein kinase (DNA-PK) activity in a patient, comprising administering to said patient an effective amount of a co-crystal containing a compound of formula:

and a co-crystal former, where the co-crystal former is adipic acid, where each of R¹ and R² is deuterium, where the molar ratio of adipic acid to the compound of formula (I) is 1:2, where the compound has reflection peaks in the powder X-ray diffraction pattern at 6.46+/-0.2, 7.91+/-0.2, 11.92+/-0.2, 12.26+/-0.2, 12.99+/-0.2, 14.19+/-0.2, 18.68+/-0.2 and 19.07+/-0.2 °2-theta, where the cancer is breast cancer, gastroesophageal cancer or lung cancer, where the therapeutic regimen involves radiotherapy or chemotherapy, and where the chemotherapy is carried out with a therapeutic agent selected from etoposide, doxorubicin and bleomycin.

EFFECT: novel method for potentiating a therapeutic regimen for treating cancer is developed, involving administering to said patient an effective amount of a co-crystal containing a compound of formula (I).

3 cl, 31 dwg, 21 tbl, 14 ex