FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to method of obtaining composition, including lyophilised one, containing epoprostenol, which includes obtaining solution of epoprostenol or its salt and arginine and bringing solution pH to more than 12 by addition of potassium hydroxide or sodium hydroxide. Invention also relates to pharmaceutical composition and stable solution for treatment of cardio-vascular diseases, which contain epoprostenol or its salt and arginin and have pH higher than 12. Also described is method of treating patient with cardio-vascular disease, which includes introduction of effective amount of said composition.
EFFECT: invention ensures obtaining hemocompatible, stable to microorganisms and stable epoprostenol compositions.
46 cl, 30 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING EPOPROSTENOL SODIUM OF INCREASED STABILITY | 2017 |
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