FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds of general formula (I) or to their pharmaceutically acceptable salts exhibiting CCR2B antagonist activity, and to a based pharmaceutical composition. 
(I) where P represents phenyl optionally substituted by 1 or 2 substitutes independently selected from halogen, C1-4alkyl, cyano, trifluoromethyl, C1-4alkoxy and trifluormethylthio, and R2 has the values specified in the patent claim.
EFFECT: preparation of new compounds of general formula (I) or their pharmaceutically acceptable salts exhibiting CCR2B antagonist activity.
16 cl, 340 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW PIPERIDINES AS CHEMOKINE (CCR) MODULATORS | 2005 |
|
RU2348616C2 |
| HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | 2010 |
|
RU2558141C2 |
| DERIVATIVES OF THIOPHEN AND PHARMACEUTICAL COMPOSIITON (VERSIONS) | 2003 |
|
RU2359967C2 |
| METHOD FOR TREATMENT OF STATES CAUSED BY p38 KINASES AND PYRROLOTRIAZINE COMPOUNDS USED AS KINASE INHIBITORS | 2001 |
|
RU2316556C2 |
| 5-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID DERIVATIVES, HAVING ANTIVIRAL ACTIVITY, SYNTHESIS METHOD THEREOF AND USE | 2007 |
|
RU2387642C2 |
| COMPOUNDS AND COMPOSITIONS AS PROTEIN TYROSINE KINASE INHIBITORS | 2006 |
|
RU2386630C2 |
| USING SIP RECEPTOR MODULATOR | 2008 |
|
RU2498796C2 |
| PYRIDINES SUBSTITUTED WITH HETEROARYL AND APPLICATION METHODS | 2017 |
|
RU2756743C2 |
| PYRAZOLO[3,4-b]PURIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITION (VERSIONS), APPLICATION (VERSIONS), COMBINATION (VERSIONS) | 2003 |
|
RU2357967C2 |
| SUBSTITUTED DERIVATIVES OF QUINAZOLINE AS AURORAKINASE INHIBITORS | 2002 |
|
RU2323215C2 |
