FIELD: chemistry.
SUBSTANCE: present invention is related to thiophen amidines of general formula I 
or their solvate, hydrate or pharmaceutically acceptable salt, where Z stands for -S(O2)-; R1 - halogen, amino, C1-6alkylthio; Ar - phenyl, piridyl, thiazolyl, phuranyl, benzothiazolyl, benzimidazolyl, every of which is not necessarily substituted; R2, R3, R4 and R7- hydrogen Compounds may be used for inhibition of ferment Cls, protease of classical pathway of complement system. Pharmaceutical compositions are also described on the basis of formula I compounds.
EFFECT: compounds may find application for treatment of certain acute and chronic immunological diseases, some neurogenerative diseases.
24 cl, 1 tbl, 337 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ARYL AND HETEROARYLETHYLACTYLGUANIDINE, PREPARING AND USING THEM IN THERAPY | 2007 |
|
RU2446165C2 |
| USING EP4 RECEPTOR ANTAGONISTS IN TREATING IL-23-MEDIATED DISEASES | 2011 |
|
RU2571816C2 |
| 4-HYDROXY-3-QUINOLINECARBOXAMIDES AND HYDRAZIDES, PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD BASED ON THEREOF | 1998 |
|
RU2220960C2 |
| TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROIDDEHYDROGENASE-1 | 2003 |
|
RU2360910C2 |
| NOVEL DERIVATIVES OF 4,5-DIHYDRO-1H-PYRAZOLE SHOWING CB-ANTAGONISTIC ACTIVITY | 2002 |
|
RU2299199C2 |
| PRODRUG 1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | 2003 |
|
RU2357962C2 |
| DERIVATIVES OF SULFAMIDE USED IN ANTHRAX TREATMENT AND INHIBITING LETHAL FACTOR | 2003 |
|
RU2289575C2 |
| NOVEL BENZIMIDAZOLE DERIVATIVES AND BASED ON THEM PHARMACEUTICAL COMPOSITION, FOR APPLICATION IN TREATMENT OF VR1-MEDIATED DISORDERS | 2004 |
|
RU2337098C2 |
| 5-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID DERIVATIVES, HAVING ANTIVIRAL ACTIVITY, SYNTHESIS METHOD THEREOF AND USE | 2007 |
|
RU2387642C2 |
| 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USING IN TREATMENT OF CARDIAC ARRHYTHMIA | 2002 |
|
RU2293085C2 |
