5-SUBSTITUTED INDOLE-3-CARBOXYLIC ACID DERIVATIVES, HAVING ANTIVIRAL ACTIVITY, SYNTHESIS METHOD THEREOF AND USE Russian patent published in 2010 - IPC C07D209/42 C07D401/06 C07D403/06 C07D413/06 C07D417/06 A61K31/40 

FIELD: chemistry.

SUBSTANCE: agent is a 6-bromo-5-methoxy-indole-3-carboxylic acid derivative of general formula (I) , where B is a N(R)₂ group, where both R groups together with the nitrogen atom to which they are bonded form a 5-6-member heterocyclic ring containing 1-2 heteroatoms selected from nitrogen, such as pyrrolidine, piperidine, piperazine or morpholine, where each of the said heterocyclic rings can be substituted with C_1-4alkyl, phenyl, benzyl, phenethyl, carbonylamino, -COOC_1-4alkyl group or -COOC_1-4alkyl group and phenyl, which can also be substituted or have substitutes selected from halogen, C_1-4alkyl, C_1-4alkoxy, and alkyl in the said groups can be linear or branched; R¹ is C_1-4alkyl, phenyl, possibly substituted with C_1-4alkyl or C_1-4alkoxy, halogen atoms; R² is -S-phenyl, -S-benzyl, -O-phenyl, where in each of the said groups, the phenyl ring is possibly substituted with C_1-4alkyl, C_1-4alkoxy, halogen atoms, or R² denotes a -N(R)₂ group, or pharmaceutically acceptable salts thereof.

EFFECT: agent has antiviral activity towards influenza A virus.

3 dwg, 2 tbl, 8 ex