UNSPITTABLE QUICKLY DECOMPOSING NEUROLEPTIC-CONTAINING FILM FOR ORAL APPLICATION Russian patent published in 2011 - IPC A61K31/551 A61K31/4515 A61K47/30 A61K47/26 A61K9/70 A61K9/22 A61P25/18 A61P25/00 

Abstract RU 2427374 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed is composition in form of one-layer, without cavities film, which does not contain surface-active substances, gas-generating additives and taste-masking agents and contains at least two film-generators, one or several gel-generators and as active substance from group of neuroleptics - olanzapine. Film-generating agents are selected from the following group: sugars, sugar alcohols and their derivatives, low-molecular organic acids, polyethylene glycol, polyethylene glycol dioleate, 1,3-butanediol, propylene glycol, glycerol, isopropyl palmitate, dibutyl sebacynate, paraffin oil and castor oil, ethylcellulose, cellulose acetate, cellulose phthalate and their mixtures. At least one film-generating agent is water-insoluble. Composition by invention is applied for preparation of medication intended for treatment of central nervous system disorders.

EFFECT: composition in form of film by invention is characterised by high mechanical strength and ability to release active substance quickly, during several seconds.

26 cl, 3 ex

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RU 2 427 374 C2

Authors

Obermajer Petra

Kor Tomas

Kramer Kaj-Tomas

Klokkers Karin

Dates

2011-08-27Published

2006-07-20Filed