COMPOSITION OF SOLID QUICK-DISINTEGRATING TABLET Russian patent published in 2013 - IPC A61K9/20 A61K47/38 A61K47/00 A61K31/00 A61J3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: composition of a solid quick-disintegrating tablet of low frangibility contains 1 to 20 wt % of ethyl cellulose as a binding agent and 2 to 15 wt % of a disintegrating agent. The ethoxy group content in ethyl cellulose is found within the range of 44 % to 54.9%. Viscosity of 5% ethyl cellulose makes a value within the range of 3 sP to 200 sP as mixed with solvents toluene/ethanol, 80:20. The disintegrating agent is specified in a group consisting of crossed-linked povidone, croscarmellose sodium salt (crossed-linked carboxymethyl cellulose sodium salt), starch glycolate sodium salt, low-substituted hydroxypropyl cellulose and guar gum. The composition may additionally contain an active pharmaceutical ingredient. What is also described is a method for preparing the quick-disintegrating tablet of low frangibility by direct compression.

EFFECT: invention provides creating the quick-disintegrating mechanically solid tablet of low frangibility for fast and effective delivery of the active ingredient into the nasal cavity.

27 cl, 8 tbl, 6 ex