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2 427 574

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(51)

IPC

C07D235/18(2006-01-01)

A61K31/4184(2006-01-01)

A61P31/10(2006-01-01)

(21) (22)

Application

2009127478/04, 2009-07-16

(24)

Start date

2009-07-16

(22)

Actual filing date

2009-07-16

(45)

Published

2011-08-27

(72)

Inventor

Velikorodov Anatolij ValerievichKovalev Vjacheslav BorisovichDegtjarev Oleg Vladimirovich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet"

MONOHYDROCHLORIDES AND SODIUM SALTS OF TAUTOMERIC 5 (6)-ALKOXYCARBONYLAMINO-DERIVATIVES OF 2-ARYL-1-HYDROXYBENZIMIDAZOLE-3-OXIDE WITH HIGH ANTIFUNGAL ACTIVITY AND SYNTHESIS METHOD THEREOF Russian patent published in 2011 - IPC C07D235/18 A61K31/4184 A61P31/10

Abstract RU 2427574 C2

FIELD: chemistry.

SUBSTANCE: antifungal agents are 5(6)-alkoxycarboxamine-derivatives of 2-aryl-1-hydroxybenzimidazole-3-oxide of formulae I , II, where R-Me, Ar=Ph (a); R=Et, Ar=Ph (b); R=PhCH₂, Ar=Ph (c); R=Me, Ar=4-BrC₆H₄ (d); R=Me, Ar=3-NO₂C₆H₄ (e), R=Me, Ar=4-MeOC₆H₄ (f). The invention also relates to a method for synthesis of said antifungal agents.

EFFECT: novel antifungal agents based on compounds of formulae I, II, have high fungicidal and fungistatic activity towards Microsporum canis, Trichophyton rubrum, Candida albicans.

3 cl, 1 tbl, 6 ex

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RU 2 427 574 C2

Authors

Velikorodov Anatolij Valerievich

Kovalev Vjacheslav Borisovich

Degtjarev Oleg Vladimirovich

Dates

2011-08-27—Published

2009-07-16—Filed