MIXED METAL COMPLEXES BASED ON 5-(4-METHYLPHENYL)-2,2'-BIPYRIDINE AND (TETRAFLUOR) SALICYLIC ACIDS, HAVING ANTIBACTERIAL AND FUNGISTATIC ACTIVITY Russian patent published in 2020 - IPC C07F1/08 C07F13/00 C07F15/06 A61K31/555 A61P31/04 A61P31/10 

Abstract RU 2737435 C1

FIELD: chemistry.

SUBSTANCE: invention relates to mixed metal complexes of 5-(4-methylphenyl)-2,2'-bipyridine and (tetrafluor) salicylic acids of general formula I:

I,

where X = H, F; M = Cu(II), Co(II), Mn(II); m = 1-2; n = 1-2. Also disclosed is a method of controlling antibacterial and fungistatic activity of mixed metal complexes by varying metal and salicylic components.

EFFECT: obtained compounds have a wide spectrum of fungistatic activity and antibacterial action on infections caused by gonococcus, Staphylococcus aureus and Staphylococcus aureus MRSA.

2 cl, 2 tbl, 4 ex

Similar patents RU2737435C1

Title Year Author Number
METAL COMPLEXES BASED ON POLYFLUORSALICYLATES AND 1,10-PHENANTHROLINE WITH ANTIBACTERIAL ACTIVITY AND A METHOD FOR PRODUCTION THEREOF 2019
  • Shchur Irina Viktorovna
  • Burgart Yanina Valerevna
  • Shchegolkov Evgenij Vadimovich
  • Gerasimova Natalya Avenirovna
  • Evstigneeva Natalya Petrovna
  • Zilberberg Natalya Vladimirovna
  • Kungurov Nikolaj Vasilevich
  • Saloutin Viktor Ivanovich
  • Chupakhin Oleg Nikolaevich
RU2706702C1
N-ARYL-4-(5-NITROFURAN-2-YL)-PYRIMIDINE-5-AMINES WITH ANTIBACTERIAL ACTIVITY AND METHOD FOR THEIR OBTAINING 2017
  • Verbitskij Egor Vladimirovich
  • Baskakova Svetlana Anatolevna
  • Gerasimova Natalya Avenirovna
  • Evstigneeva Natalya Petrovna
  • Zilberberg Natalya Vladimirovna
  • Kungurov Nikolaj Vasilevich
  • Rusinov Gennadij Leonidovich
  • Chupakhin Oleg Nikolaevich
  • Charushin Valerij Nikolaevich
RU2642428C1
4-(4-METHOXYPHENYL DIAZENYL)-3,5-DIMETHYL-1-(4-NITROPHENYL)-1H-PYRAZOLE WITH ANTIMYCOTIC ACTIVITY AGAINST STRAINS OF PATHOGENIC DERMATOPHYTE FUNGI 2021
  • Khudina Olga Georgievna
  • Saloutin Viktor Ivanovich
  • Burgart Yanina Valerevna
  • Gerasimova Natalya Avenirovna
  • Evstigneeva Natalya Petrovna
  • Zilberberg Natalya Vladimirovna
  • Kungurov Nikolaj Vasilevich
RU2772381C1
4-ISOPROPYL-6-R-IMIDAZO[1,2-B][1,2,4,5]TETRAZIN-3(4H)- ES WITH ANTIBACTERIAL ACTIVITY AGAINST NEISSERIA GONORRHOEAE 2020
  • Charushin Valerij Nikolaevich
  • Korotina Anna Vladimirovna
  • Tolshchina Svetlana Gennadevna
  • Ishmetova Rashida Irshotovna
  • Gerasimova Natalya Avenirovna
  • Evstigneeva Natalya Petrovna
  • Zilberberg Natalya Vladimirovna
  • Kungurov Nikolaj Vasilevich
  • Rusinov Gennadij Leonidovich
  • Chupakhin Oleg Nikolaevich
RU2754554C1
(1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)METHYL (Z)-2-((3S,4S,8S,10S,11R,14S,16S)-16-ACETOXY-3,11 -DIHYDROXY-4,8,10,14-TETRAMETHYLHEXADECAHYDRO-17H-CYCLOPENTA[a]PHENANTHRENE-17-YLIDENE)-6-METHYLHEPT-5-ENOATE EXHIBITING ANTIBACTERIAL AND FUNGICIDAL ACTIVITY 2022
  • Salimova Elena Viktorovna
  • Parfenova Liudmila Viacheslavovna
RU2784215C1
5-ARYL-SUSTITUTED 4-(5-NITROFURAN-2-YL)PYRIMIDINE, WITH WIDE SPECTRUM OF ANTIBACTERIAL ACTIVITY, METHOD FOR ITS PRODUCTION AND INTERMEDIATE COMPOUND WITH WIDE SPECTRUM OF ANTIBACTERIAL ACTIVITY 2016
  • Verbitskij Egor Vladimirovich
  • Baskakova Svetlana Anatolevna
  • Gerasimova Natalya Avenirovna
  • Evstigneeva Natalya Petrovna
  • Amineva Polina Gennadevna
  • Zilberberg Natalya Vladimirovna
  • Kungurov Nikolaj Vasilevich
  • Rusinov Gennadij Leonidovich
  • Chupakhin Oleg Nikolaevich
  • Charushin Valerij Nikolaevich
RU2626647C1
SELECTIVE ANTIBACTERIAL AGENTS, REPRESENTED BY 3-(AZOL-1-YL)-6-AMINO-SUBSTITUTED 1,2,4,5-TETRAZINES 2017
  • Ishmetova Rashida Irshotovna
  • Ignatenko Nina Konstantinovna
  • Belyaninova Irina Aleksandrovna
  • Gerasimova Natalya Avenirovna
  • Evstigneeva Natalya Petrovna
  • Zilberberg Natalya Vladimirovna
  • Kungurov Nikolaj Vasilevich
  • Rusinov Gennadij Leonidovich
  • Charushin Valerij Nikolaevich
  • Chupakhin Oleg Nikolaevich
RU2642882C1
SILVER SALTS OF 5,6-DIARYL-4-[4-(ACETYLAMINOSULPHONYL)PHENYL]-3,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-ONES EXHIBITING ANTIMICROBIAL ACTIVITY 2019
  • Gejn Vladimir Leonidovich
  • Bobrovskaya Olga Vasilevna
  • Seliverstov Grigorij Vladimirovich
  • Novikova Valentina Vasilevna
  • Makhmudov Ramiz Ragibovich
RU2698328C1
METHOD FOR OVERCOMING GENTAMYCIN RESISTANCE IN METHICILLIN-RESISTANT S. AUREUS STRAINS 2013
  • Bozhkova Svetlana Anatol'Evna
  • Krasnova Margarita Viktorovna
  • Poljakova Ekaterina Mikhajlovna
  • Bogdanova Tat'Jana Jakovlevna
RU2553601C2
4-[(4-BROMOPHENYL)((4-NITROPHENYL)AMINO)METHYLIDENE]-5-HYDROXY-5-(TRICHLOROMETHYL)DIHYDROFURAN-2,3-DIONE WITH ANTIMICROBIAL ACTIVITY 2022
  • Lisovenko Natalia Iurevna
  • Kharitonova Svetlana Sergeevna
  • Balandina Svetlana Iurevna
  • Myshkina Olga Andreevna
RU2783242C1

RU 2 737 435 C1

Authors

Shchur Irina Viktorovna

Burgart Yanina Valerevna

Shchegolkov Evgenij Vadimovich

Gerasimova Natalya Avenirovna

Evstigneeva Natalya Petrovna

Zilberberg Natalya Vladimirovna

Kopchuk Dmitrij Sergeevich

Zyryanov Grigorij Vasilevich

Kungurov Nikolaj Vasilevich

Saloutin Viktor Ivanovich

Chupakhin Oleg Nikolaevich

Dates

2020-11-30Published

2020-04-30Filed