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IPC

C07C211/40(2006-01-01)

C07C219/24(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2009149126/04, 2009-12-28

(24)

Start date

2009-12-28

(22)

Actual filing date

2009-12-28

(45)

Published

2011-09-10

(72)

Inventor

Prusakova Anna SergeevnaGejn Vladimir LeonidovichNosova Natal'Ja VladimirovnaSyropjatov Boris JakovlevichKovaleva Marina Jur'EvnaMarkova Ljubov' Nikolaevna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Farmatsevticheskaja Akademija Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju" Vpo Pgfa Roszdrava)

DIMETHYL 4-PHENYLETHYLAMINO-2-(4-METHOXYPHENYL)-6-HYDROXY-6-METHYL-3-CYCLOHEXENE-1,3-DICARBOXYLATE EXHIBITING ANTI-INFLAMMATORY ACTION Russian patent published in 2011 - IPC C07C211/40 C07C219/24 A61P29/00

Abstract RU 2428410 C1

FIELD: chemistry.

SUBSTANCE: compound has formula (I):

The compound is obtained through arylamination of 2-(4-methoxyphenyl)-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxylate with phenylethylamine in the presence of acetic acid in ethanol. The compound is a yellow crystalline substance with T_m=130°C, which is soluble in dimethyl sulphoxide (DMSO) and dimethyl formamide (DMFA) but not soluble in water. LD₅₀ during intraperitoneal administration to white mice was greater than 10000 mg/kg.

EFFECT: high anti-inflammatory action of the compound.

1 tbl

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RU 2 428 410 C1

Authors

Prusakova Anna Sergeevna

Gejn Vladimir Leonidovich

Nosova Natal'Ja Vladimirovna

Syropjatov Boris Jakovlevich

Kovaleva Marina Jur'Evna

Markova Ljubov' Nikolaevna

Dates

2011-09-10—Published

2009-12-28—Filed