PHARMACEUTICAL COMPOSITION FOR TREATING FUNGOID DISEASES Russian patent published in 2011 - IPC A61K31/7048 A61K31/721 A61K47/24 A61K47/40 A61P31/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, medicine and pharmacology, particularly to invention refers to, and can be used in development of antimycotic preparations of amphotericin B exhibiting low nephro- and hepatotoxicity. For the purpose of providing higher therapeutic efficacy, lower toxicity of a pharmaceutical composition, improved stability of amphotericin B as an ingredient, it contains oxidised dextrane produced by dextrane oxidation by potassium permanganate in an acid medium. It also contains a liposome-forming agent representing phosphatidylcholine. The ingredients of the pharmaceutical composition are related as follows: amphotericin B: oxidised dextrane: a liposome-forming agent: a pharmaceutically acceptable solvent as 0.0005:1-10:0.1-1.0:solvent up to 100 wt % respectively.

EFFECT: composition shows high efficacy.

2 cl, 3 ex