PHARMACEUTICAL TUBERCULOSIS COMPOSITION Russian patent published in 2009 - IPC A61K31/4409 A61K31/721 A61K9/127 A61K47/48 A61P31/06 

FIELD: medicine.

SUBSTANCE: invention refers to medical products, particularly to pharmaceutical tuberculosis composition containing isoniazid conjugate with oxidised dextrane of molecular weight 35-60 kDa purified from free isoniasid and cytotoxic impurities, e.g. by spirit sedimentation at temperature 60-80°C. Additionally, the pharmaceutical composition contains a liposome-forming agent, e.g. phosphatidylcholine, pharmaceutically acceptable excipient, e.g. water for injection, saline or buffer solution. The component ratio is as follows: isoniasid conjugate with oxidised dextrane - 0.4-4.0 wt %, the liposome-forming agent - 0.1-1.0 wt %, the pharmaceutically acceptable excipient - to 100 wt %. The pharmaceutical composition represents nanoliposome emulsions of liposome size 150-800 nm.

EFFECT: lower hepatotoxicity and improved biocompatibility.

5 cl, 2 tbl, 3 ex