METHOD OF PRODUCING OXIDISED DEXTRAN, SUITABLE FOR ITS VISUALIZATION IN BLOOD SERUM Russian patent published in 2019 - IPC C08B37/02 A61K31/721 A61K49/00 G01N33/532 

FIELD: manufacturing technology.

SUBSTANCE: invention relates to a method of producing an oxidized dextran, suitable for its visualization in blood serum, involving reaction of oxidized dextran with a label for imaging thereof at temperature of 80–90 °C, as a mark for imaging is used acridonacetic acid hydrazide; reaction of acridonacetic acid hydrazine – oxidized dextran is carried out at a ratio of components of 1:10 respectively in terms of weight of dry substance for 90 minutes, filtering the obtained suspension, cooling it to room temperature, adding a liposome-forming agent, holding the obtained liposomal form of the oxidized dextran derivative at temperature of 4–6 °C for at least 24 hours, then filtering it using a microfilter.

EFFECT: obtaining an oxidized dextran derivative which enables to determine content of its liposomal forms in blood serum.

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